In a shallow dish, soak the catfish fillets in buttermilk for at least 30 minutes to tenderize
In a separate bowl, mix cornmeal, flour, salt, black pepper, paprika, garlic powder, onion powder, cayenne pepper, and baking powder
Heat vegetable oil in a deep skillet or fryer to 350°F (175°C)
Remove catfish fillets from buttermilk and dredge in the seasoned cornmeal mixture, coating evenly
Carefully place fillets in the hot oil and fry for about 4-5 minutes per side until golden brown and crispy
Remove and drain on a wire rack or paper towels
Serve hot with lemon wedges and your favorite Southern sides